Cell and Applied Biology (BIOS-10/A)
The research activity of the Cell and Applied Biology Section (BIOS-10/A) focuses on the development of experimental approaches in regenerative medicine, based on the study of stem cells, with particular interest in mesenchymal stromal cells (MSCs), isolated from different perinatal and adult tissue sources, in their involvement in congenital and acquired diseases, and in their application in tissue regeneration in disease models.
The activity is expressed in different research topics:
- Study of the immune-modulatory properties of MSCs isolated from amniotic membrane and their derivatives (secretome, extracellular vesicles) and their application in preclinical models of inflammatory and immune-mediated diseases
- Study of the skull stem niche and molecular mechanisms in the etiopathogenesis of congenital malformation diseases, identification of therapeutic targets and new disease markers, and evaluation of cellular interaction with nanomaterials and biocomposites for tissue engineering aimed at bone regeneration
- Study of the muscle stem niche and the epigenetic mechanisms that regulate muscle differentiation, for the development of innovative therapies in diseases characterized by muscle degeneration and fibrosis.
The teaching staff of the Section carries out teaching activities in the disciplines related to SSDBIOS-10/A in the integrated degree courses in Medicine and Surgery, Medicine and Surgery, Dentistry and Dental Prosthetics, and Pharmacy; in the Master's Degree Course in Biotechnology for Personalized Medicine, and in the three-year degree courses in the health professions active in the Faculty of Medicine and Surgery of the Catholic University of the Sacred Heart.
